6LU7

The crystal structure of COVID-19 main protease in complex with an inhibitor N3

6LU7 の概要

• エントリーDOI: 10.2210/pdb6lu7/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002214
• 分子名称: 3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE (3 entities in total)
• 機能のキーワード: protease, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34506.34

構造登録者

Liu, X.,Zhang, B.,Jin, Z.,Yang, H.,Rao, Z. (登録日: 2020-01-26, 公開日: 2020-02-05, 最終更新日: 2023-11-29)

• 主引用文献: Jin, Z.,Du, X.,Xu, Y.,Deng, Y.,Liu, M.,Zhao, Y.,Zhang, B.,Li, X.,Zhang, L.,Peng, C.,Duan, Y.,Yu, J.,Wang, L.,Yang, K.,Liu, F.,Jiang, R.,Yang, X.,You, T.,Liu, X.,Yang, X.,Bai, F.,Liu, H.,Liu, X.,Guddat, L.W.,Xu, W.,Xiao, G.,Qin, C.,Shi, Z.,Jiang, H.,Rao, Z.,Yang, H.; Structure of Mprofrom SARS-CoV-2 and discovery of its inhibitors.; Nature, 582:289-293, 2020; PubMed: 32272481; DOI: 10.1038/s41586-020-2223-y

実験手法

X-RAY DIFFRACTION (2.16 Å)