6LPQ

Crystal structure of human D-2-hydroxyglutarate dehydrogenase in complex with D-malate (D-MAL)

Summary for 6LPQ

• Entry DOI: 10.2210/pdb6lpq/pdb
• Descriptor: D-2-hydroxyglutarate dehydrogenase, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ZINC ION, ... (4 entities in total)
• Functional Keywords: dehydrogenase, flavoprotein, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 106635.84

Authors

Yang, J.,Zhu, H.,Ding, J. (deposition date: 2020-01-12, release date: 2021-01-13, Last modification date: 2023-11-29)

• Primary citation: Yang, J.,Zhu, H.,Zhang, T.,Ding, J.; Structure, substrate specificity, and catalytic mechanism of human D-2-HGDH and insights into pathogenicity of disease-associated mutations.; Cell Discov, 7:3-3, 2021; PubMed: 33431826; DOI: 10.1038/s41421-020-00227-0

Experimental method

X-RAY DIFFRACTION (2.8 Å)