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6LP6

Crystal structure of human DHODH in complex with inhibitor 1214

Summary for 6LP6
Entry DOI10.2210/pdb6lp6/pdb
DescriptorDihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (9 entities in total)
Functional Keywordsdhodh, inhibitor, oxidoreductase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight41558.86
Authors
Chen, Q.,Yu, Y. (deposition date: 2020-01-09, release date: 2020-09-30, Last modification date: 2023-11-29)
Primary citationZuo, Z.,Liu, X.,Qian, X.,Zeng, T.,Sang, N.,Liu, H.,Zhou, Y.,Tao, L.,Zhou, X.,Su, N.,Yu, Y.,Chen, Q.,Luo, Y.,Zhao, Y.
Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63:7633-7652, 2020
Cited by
PubMed: 32496056
DOI: 10.1021/acs.jmedchem.0c00512
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.795 Å)
Structure validation

217705

数据于2024-03-27公开中

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