6LP6

Crystal structure of human DHODH in complex with inhibitor 1214

6LP6 の概要

• エントリーDOI: 10.2210/pdb6lp6/pdb
• 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (9 entities in total)
• 機能のキーワード: dhodh, inhibitor, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41558.86

構造登録者

Chen, Q.,Yu, Y. (登録日: 2020-01-09, 公開日: 2020-09-30, 最終更新日: 2023-11-29)

• 主引用文献: Zuo, Z.,Liu, X.,Qian, X.,Zeng, T.,Sang, N.,Liu, H.,Zhou, Y.,Tao, L.,Zhou, X.,Su, N.,Yu, Y.,Chen, Q.,Luo, Y.,Zhao, Y.; Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.; J.Med.Chem., 63:7633-7652, 2020; PubMed: 32496056; DOI: 10.1021/acs.jmedchem.0c00512

実験手法

X-RAY DIFFRACTION (1.795 Å)