6LJU
Crystal structure of human FABP4 in complex with a novel inhibitor
Summary for 6LJU
Entry DOI | 10.2210/pdb6lju/pdb |
Descriptor | Fatty acid-binding protein, adipocyte, 2-[[3-chloranyl-4-(methylamino)-2-phenyl-phenyl]amino]benzoic acid, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | fabp4, inhibitor, complex, lipid binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 17326.15 |
Authors | Su, H.X.,Zhang, X.L.,Li, M.J.,Xu, Y.C. (deposition date: 2019-12-17, release date: 2020-04-15, Last modification date: 2023-11-22) |
Primary citation | Su, H.,Zou, Y.,Chen, G.,Dou, H.,Xie, H.,Yuan, X.,Zhang, X.,Zhang, N.,Li, M.,Xu, Y. Exploration of Fragment Binding Poses Leading to Efficient Discovery of Highly Potent and Orally Effective Inhibitors of FABP4 for Anti-inflammation. J.Med.Chem., 63:4090-4106, 2020 Cited by PubMed: 32202425DOI: 10.1021/acs.jmedchem.9b02107 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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