6LJT

Crystal structure of human FABP4 in complex with a novel inhibitor

6LJT の概要

• エントリーDOI: 10.2210/pdb6ljt/pdb
• 分子名称: Fatty acid-binding protein, adipocyte, 2-[(3-chloranyl-2-phenyl-phenyl)amino]benzoic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: fabp4, inhibitor, complex, lipid binding protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17297.11

構造登録者

Su, H.X.,Zhang, X.L.,Li, M.J.,Xu, Y.C. (登録日: 2019-12-17, 公開日: 2020-04-15, 最終更新日: 2023-11-22)

• 主引用文献: Su, H.,Zou, Y.,Chen, G.,Dou, H.,Xie, H.,Yuan, X.,Zhang, X.,Zhang, N.,Li, M.,Xu, Y.; Exploration of Fragment Binding Poses Leading to Efficient Discovery of Highly Potent and Orally Effective Inhibitors of FABP4 for Anti-inflammation.; J.Med.Chem., 63:4090-4106, 2020; PubMed: 32202425; DOI: 10.1021/acs.jmedchem.9b02107

実験手法

X-RAY DIFFRACTION (1.45 Å)