6LHM

Structure of human PYCR2

Summary for 6LHM

Entry DOI	10.2210/pdb6lhm/pdb
Descriptor	Pyrroline-5-carboxylate reductase 2 (1 entity in total)
Functional Keywords	pycr2, carboxylate, p5cr, decamer, pentamer, pyrroline-5-carboxylate reductase, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	5
Total formula weight	158689.09
Authors	Baburajendran, N. (deposition date: 2019-12-09, release date: 2020-10-28, Last modification date: 2023-11-22)
Primary citation	Escande-Beillard, N.,Loh, A.,Saleem, S.N.,Kanata, K.,Hashimoto, Y.,Altunoglu, U.,Metoska, A.,Grandjean, J.,Ng, F.M.,Pomp, O.,Baburajendran, N.,Wong, J.,Hill, J.,Beillard, E.,Cozzone, P.,Zaki, M.,Kayserili, H.,Hamada, H.,Shiratori, H.,Reversade, B. Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2. Neuron, 107:82-94.e6, 2020 Cited by PubMed: 32330411 DOI: 10.1016/j.neuron.2020.03.028 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation