6LHM
Structure of human PYCR2
Summary for 6LHM
Entry DOI | 10.2210/pdb6lhm/pdb |
Descriptor | Pyrroline-5-carboxylate reductase 2 (1 entity in total) |
Functional Keywords | pycr2, carboxylate, p5cr, decamer, pentamer, pyrroline-5-carboxylate reductase, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 5 |
Total formula weight | 158689.09 |
Authors | Baburajendran, N. (deposition date: 2019-12-09, release date: 2020-10-28, Last modification date: 2023-11-22) |
Primary citation | Escande-Beillard, N.,Loh, A.,Saleem, S.N.,Kanata, K.,Hashimoto, Y.,Altunoglu, U.,Metoska, A.,Grandjean, J.,Ng, F.M.,Pomp, O.,Baburajendran, N.,Wong, J.,Hill, J.,Beillard, E.,Cozzone, P.,Zaki, M.,Kayserili, H.,Hamada, H.,Shiratori, H.,Reversade, B. Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2. Neuron, 107:82-94.e6, 2020 Cited by PubMed: 32330411DOI: 10.1016/j.neuron.2020.03.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
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