6LG5

Crystal Structure of the first bromodomain of human BRD4 in complex with compound BDF-1038

Summary for 6LG5

• Entry DOI: 10.2210/pdb6lg5/pdb
• Descriptor: Bromodomain-containing protein 4, 1-[(5-chloranyl-8-oxidanyl-quinolin-7-yl)methyl]pyrrolidin-2-one (3 entities in total)
• Functional Keywords: brd4, inhibitor, complex, dna binding protein, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15159.91

Authors

Xu, H.,Zuo, Y.,Zhang, H. (deposition date: 2019-12-04, release date: 2020-12-09, Last modification date: 2023-11-22)

• Primary citation: Xu, H.,Zuo, Y.; Lead-Opt: An efficient tool for structural optimization of lead compounds; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.83 Å)