6LB5

Crystal structure of dimeric RXR-LBD complexed with full agonist NEt-3IB and TIF2 co-activator

6LB5 の概要

• エントリーDOI: 10.2210/pdb6lb5/pdb
• 分子名称: Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, 6-[ethyl-[3-(2-methylpropoxy)-4-propan-2-yl-phenyl]amino]pyridine-3-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: nuclear receptor, retinoid x receptor alpha, active form, co-factors, partial agonist, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 58121.24

構造登録者

Imai, D.,Numoto, N.,Nakano, S.,Kakuta, H.,Ito, N. (登録日: 2019-11-13, 公開日: 2020-11-18, 最終更新日: 2024-10-02)

• 主引用文献: Imai, D.,Numoto, N.,Tokiwa, H.,Kakuta, H.,Ito, N.; Structural basis for the full and partial agonist activities of retinoid X receptor alpha ligands with an iso-butoxy and an isopropyl group; Biochem.Biophys.Res.Commun., 734:150617-, 2024; DOI: 10.1016/j.bbrc.2024.150617

実験手法

X-RAY DIFFRACTION (2.4 Å)