6L8L

C-Src in complex with ibrutinib

Summary for 6L8L

• Entry DOI: 10.2210/pdb6l8l/pdb
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one (3 entities in total)
• Functional Keywords: kinase, transferase
• Biological source: Gallus gallus (Chicken)
• Total number of polymer chains: 4
• Total formula weight: 132668.57

Authors

Guo, M.,Dai, S.,Chen, L.,Chen, Y. (deposition date: 2019-11-06, release date: 2020-11-11, Last modification date: 2023-11-22)

• Primary citation: Guo, M.,Dai, S.,Wu, D.,Duan, Y.,Li, J.,Qu, L.,Jiang, L.,Chen, Z.,Chen, X.,Chen, Y.; Characterization of ibrutinib as a non-covalent inhibitor of SRC-family kinases.; Bioorg.Med.Chem.Lett., 34:127757-127757, 2020; PubMed: 33359446; DOI: 10.1016/j.bmcl.2020.127757

Experimental method

X-RAY DIFFRACTION (2.888 Å)