6L8L
C-Src in complex with ibrutinib
Summary for 6L8L
Entry DOI | 10.2210/pdb6l8l/pdb |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one (3 entities in total) |
Functional Keywords | kinase, transferase |
Biological source | Gallus gallus (Chicken) |
Total number of polymer chains | 4 |
Total formula weight | 132668.57 |
Authors | |
Primary citation | Guo, M.,Dai, S.,Wu, D.,Duan, Y.,Li, J.,Qu, L.,Jiang, L.,Chen, Z.,Chen, X.,Chen, Y. Characterization of ibrutinib as a non-covalent inhibitor of SRC-family kinases. Bioorg.Med.Chem.Lett., 34:127757-127757, 2020 Cited by PubMed: 33359446DOI: 10.1016/j.bmcl.2020.127757 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.888 Å) |
Structure validation
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