6L76

Crystal structure of the Ni(II)(Chro)2-d(TTGGGCCGAA/TTCGGCCCAA) complex at 2.94 angstrom resolution

6L76 の概要

• エントリーDOI: 10.2210/pdb6l76/pdb
• 分子名称: DNA (5'-D(*TP*TP*GP*GP*GP*CP*CP*GP*AP*A)-3'), DNA (5'-D(*TP*TP*CP*GP*GP*CP*CP*CP*AP*A)-3'), 2,6-dideoxy-4-O-methyl-alpha-D-galactopyranose-(1-3)-(2R,3R,6R)-6-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate, ... (7 entities in total)
• 機能のキーワード: duplex dna, ggggcc motif, nucleotide flipping-out, hoogsteen base pair, dna
• 由来する生物種: synthetic construct; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 17275.98

構造登録者

Hou, M.H.,Jhan, C.R.,Satange, R.B.,Lin, S.M. (登録日: 2019-10-31, 公開日: 2021-01-13, 最終更新日: 2023-11-22)

• 主引用文献: Jhan, C.R.,Satange, R.,Wang, S.C.,Zeng, J.Y.,Horng, Y.C.,Jin, P.,Neidle, S.,Hou, M.H.; Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction.; Nucleic Acids Res., 49:9526-9538, 2021; PubMed: 33836081; DOI: 10.1093/nar/gkab227

実験手法

X-RAY DIFFRACTION (2.94 Å)