6L6H

Crystal structure of Lpg0189

Summary for 6L6H

• Entry DOI: 10.2210/pdb6l6h/pdb
• Descriptor: Uncharacterized protein Lpg0189, GLYCEROL, ACETATE ION, ... (4 entities in total)
• Functional Keywords: lpg0189, legionella pneumophila, novel fold, t2ss effector, unknown function
• Biological source: Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
• Total number of polymer chains: 2
• Total formula weight: 62911.10

Authors

Ge, H.,Chen, X. (deposition date: 2019-10-29, release date: 2019-11-27, Last modification date: 2024-10-16)

Primary citation

Chen, X.,Liu, S.,Jiang, S.,Zhang, X.,Zhang, N.,Ma, J.,Ge, H.
Crystal structure of a hypothetical T2SS effector Lpg0189 from Legionella pneumophila reveals a novel protein fold.
Biochem.Biophys.Res.Commun., 521:799-805, 2020

PubMed Abstract: Lpg0189 is a type II secretion system-dependent extracellular protein with unknown function from Legionella pneumophila. Herein, we determined the crystal structure of Lpg0189 at 1.98 Å resolution by using single-wavelength anomalous diffraction (SAD). Lpg0189 folds into a novel chair-shaped architecture, with two sheets roughly perpendicular to each other. Bioinformatics analysis suggests Lpg0189 and its homologues are unique to Legionellales and evolved divergently. The interlinking structural and bioinformatics studies provide a better understanding of this hypothetical protein.

PubMed: 31706575
DOI: 10.1016/j.bbrc.2019.10.195

Experimental method

X-RAY DIFFRACTION (2.403 Å)