6L6H

Crystal structure of Lpg0189

6L6H の概要

• エントリーDOI: 10.2210/pdb6l6h/pdb
• 分子名称: Uncharacterized protein Lpg0189, GLYCEROL, ACETATE ION, ... (4 entities in total)
• 機能のキーワード: lpg0189, legionella pneumophila, novel fold, t2ss effector, unknown function
• 由来する生物種: Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62911.10

構造登録者

Ge, H.,Chen, X. (登録日: 2019-10-29, 公開日: 2019-11-27, 最終更新日: 2024-10-16)

主引用文献

Chen, X.,Liu, S.,Jiang, S.,Zhang, X.,Zhang, N.,Ma, J.,Ge, H.
Crystal structure of a hypothetical T2SS effector Lpg0189 from Legionella pneumophila reveals a novel protein fold.
Biochem.Biophys.Res.Commun., 521:799-805, 2020

PubMed Abstract: Lpg0189 is a type II secretion system-dependent extracellular protein with unknown function from Legionella pneumophila. Herein, we determined the crystal structure of Lpg0189 at 1.98 Å resolution by using single-wavelength anomalous diffraction (SAD). Lpg0189 folds into a novel chair-shaped architecture, with two sheets roughly perpendicular to each other. Bioinformatics analysis suggests Lpg0189 and its homologues are unique to Legionellales and evolved divergently. The interlinking structural and bioinformatics studies provide a better understanding of this hypothetical protein.

PubMed: 31706575
DOI: 10.1016/j.bbrc.2019.10.195

実験手法

X-RAY DIFFRACTION (2.403 Å)