6L2Q

Threonyl-tRNA synthetase from Salmonella enterica in complex with an inhibitor

6L2Q の概要

• エントリーDOI: 10.2210/pdb6l2q/pdb
• 分子名称: Threonine--tRNA ligase, ZINC ION, (2S,3R)-2-azanyl-N-[(E)-4-[6,7-bis(chloranyl)-4-oxidanylidene-quinazolin-3-yl]but-2-enyl]-3-oxidanyl-butanamide, ... (5 entities in total)
• 機能のキーワード: trna synthetase, drug target, homodimer, ligase
• 由来する生物種: Salmonella enterica subsp. enterica serovar Cubana str. 76814
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 96892.40

構造登録者

Guo, J.,Chen, B.,Zhou, H. (登録日: 2019-10-05, 公開日: 2020-01-15, 最終更新日: 2023-11-22)

• 主引用文献: Guo, J.,Chen, B.,Yu, Y.,Cheng, B.,Cheng, Y.,Ju, Y.,Gu, Q.,Xu, J.,Zhou, H.; Discovery of novel tRNA-amino acid dual-site inhibitors against threonyl-tRNA synthetase by fragment-based target hopping.; Eur.J.Med.Chem., 187:111941-111941, 2019; PubMed: 31821989; DOI: 10.1016/j.ejmech.2019.111941

実験手法

X-RAY DIFFRACTION (2.3 Å)