6L0I
Crystal structure of dihydroorotase in complex with malate at pH6.5 from Saccharomyces cerevisiae
Summary for 6L0I
Entry DOI | 10.2210/pdb6l0i/pdb |
Related | 6L0A 6L0B 6L0F 6L0G 6L0H |
Descriptor | Dihydroorotase, ZINC ION, (2S)-2-hydroxybutanedioic acid, ... (4 entities in total) |
Functional Keywords | dihydropyrimidinase dihydroorotase metalloenzyme, hydrolase |
Biological source | Saccharomyces cerevisiae S288C (Baker's yeast) |
Total number of polymer chains | 4 |
Total formula weight | 166973.04 |
Authors | Guan, H.H.,Huang, Y.H.,Huang, C.Y.,Chen, C.J. (deposition date: 2019-09-26, release date: 2020-12-02, Last modification date: 2023-11-22) |
Primary citation | Guan, H.H.,Huang, Y.H.,Lin, E.S.,Chen, C.J.,Huang, C.Y. Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil. Biochem.Biophys.Res.Commun., 551:33-37, 2021 Cited by PubMed: 33714757DOI: 10.1016/j.bbrc.2021.03.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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