6L0I

Crystal structure of dihydroorotase in complex with malate at pH6.5 from Saccharomyces cerevisiae

Summary for 6L0I

Entry DOI	10.2210/pdb6l0i/pdb
Related	6L0A 6L0B 6L0F 6L0G 6L0H
Descriptor	Dihydroorotase, ZINC ION, (2S)-2-hydroxybutanedioic acid, ... (4 entities in total)
Functional Keywords	dihydropyrimidinase dihydroorotase metalloenzyme, hydrolase
Biological source	Saccharomyces cerevisiae S288C (Baker's yeast)
Total number of polymer chains	4
Total formula weight	166973.04
Authors	Guan, H.H.,Huang, Y.H.,Huang, C.Y.,Chen, C.J. (deposition date: 2019-09-26, release date: 2020-12-02, Last modification date: 2023-11-22)
Primary citation	Guan, H.H.,Huang, Y.H.,Lin, E.S.,Chen, C.J.,Huang, C.Y. Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil. Biochem.Biophys.Res.Commun., 551:33-37, 2021 Cited by PubMed: 33714757 DOI: 10.1016/j.bbrc.2021.03.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation