6KZP

calcium channel-ligand

6KZP の概要

• エントリーDOI: 10.2210/pdb6kzp/pdb
• EMDBエントリー: 0792
• 分子名称: Voltage-dependent T-type calcium channel subunit alpha-1G,Voltage-dependent T-type calcium channel subunit alpha-1G, CALCIUM ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: channel, blocker, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 247668.56

構造登録者

Yan, N. (登録日: 2019-09-25, 公開日: 2019-12-18, 最終更新日: 2024-11-06)

主引用文献

Zhao, Y.,Huang, G.,Wu, Q.,Wu, K.,Li, R.,Lei, J.,Pan, X.,Yan, N.
Cryo-EM structures of apo and antagonist-bound human Cav3.1.
Nature, 576:492-497, 2019

PubMed Abstract: Among the ten subtypes of mammalian voltage-gated calcium (Ca) channels, Ca3.1-Ca3.3 constitute the T-type, or the low-voltage-activated, subfamily, the abnormal activities of which are associated with epilepsy, psychiatric disorders and pain. Here we report the cryo-electron microscopy structures of human Ca3.1 alone and in complex with a highly Ca3-selective blocker, Z944, at resolutions of 3.3 Å and 3.1 Å, respectively. The arch-shaped Z944 molecule reclines in the central cavity of the pore domain, with the wide end inserting into the fenestration on the interface between repeats II and III, and the narrow end hanging above the intracellular gate like a plug. The structures provide the framework for comparative investigation of the distinct channel properties of different Ca subfamilies.

PubMed: 31766050
DOI: 10.1038/s41586-019-1801-3

実験手法

ELECTRON MICROSCOPY (3.1 Å)