6KZ5

Crystal Structure Analysis of the Csn-B-bounded NUR77 Ligand binding Domain

Summary for 6KZ5

• Entry DOI: 10.2210/pdb6kz5/pdb
• Descriptor: Nuclear receptor subfamily 4 group A member 1, ethyl 2-[2-octanoyl-3,5-bis(oxidanyl)phenyl]ethanoate (2 entities in total)
• Functional Keywords: nr4a1, nur77, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 57813.01

Authors

Hong, W.,Chen, H.,Wu, Q.,Lin, T. (deposition date: 2019-09-23, release date: 2020-10-14, Last modification date: 2023-11-22)

• Primary citation: Yang, P.B.,Hou, P.P.,Liu, F.Y.,Hong, W.B.,Chen, H.Z.,Sun, X.Y.,Li, P.,Zhang, Y.,Ju, C.Y.,Luo, L.J.,Wu, S.F.,Zhou, J.X.,Wang, Z.J.,He, J.P.,Li, L.,Zhao, T.J.,Deng, X.,Lin, T.,Wu, Q.; Blocking PPAR gamma interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression.; Proc.Natl.Acad.Sci.USA, 117:27412-27422, 2020; PubMed: 33087562; DOI: 10.1073/pnas.2002997117

Experimental method

X-RAY DIFFRACTION (4.45 Å)