6KUB

Crystal structure of Plasmodium falciparum histo-aspartic protease (HAP) zymogen (Form 1)

Summary for 6KUB

Entry DOI	10.2210/pdb6kub/pdb
Descriptor	HAP protein, GLYCEROL, DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
Functional Keywords	histo-aspartic protease, hap, plasmepsin, proplasmepsin, zymogen, aspartic protease, hydrolase
Biological source	Plasmodium falciparum
Total number of polymer chains	1
Total formula weight	43919.70
Authors	Rathore, I.,Mishra, V.,Bhaumik, P. (deposition date: 2019-08-31, release date: 2020-05-27, Last modification date: 2023-11-22)
Primary citation	Rathore, I.,Mishra, V.,Patel, C.,Xiao, H.,Gustchina, A.,Wlodawer, A.,Yada, R.Y.,Bhaumik, P. Activation mechanism of plasmepsins, pepsin-like aspartic proteases from Plasmodium, follows a unique trans-activation pathway. Febs J., 288:678-698, 2021 Cited by PubMed: 32385863 DOI: 10.1111/febs.15363 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation