6KRH

Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis

6KRH の概要

• エントリーDOI: 10.2210/pdb6krh/pdb
• 分子名称: DNA ligase A, ADENOSINE MONOPHOSPHATE, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: ligase
• 由来する生物種: Mycobacterium tuberculosis H37Rv
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37995.89

構造登録者

Ramachandran, R.,Shukla, A.,Afsar, M. (登録日: 2019-08-21, 公開日: 2020-08-26, 最終更新日: 2023-11-22)

• 主引用文献: Afsar, M.,Shukla, A.,Kumar, N.,Ramachandran, R.; Salt bridges at the subdomain interfaces of the adenylation domain and active-site residues of Mycobacterium tuberculosis NAD + -dependent DNA ligase A (MtbLigA) are important for the initial steps of nick-sealing activity.; Acta Crystallogr D Struct Biol, 77:776-789, 2021; PubMed: 34076591; DOI: 10.1107/S2059798321003107

実験手法

X-RAY DIFFRACTION (2.6 Å)