6KOG

Ketosynthase domain in tenuazonic acid synthetase 1 (TAS1).

Summary for 6KOG

• Entry DOI: 10.2210/pdb6kog/pdb
• Descriptor: Hybrid PKS-NRPS synthetase TAS1, GLYCEROL, SULFATE ION, ... (4 entities in total)
• Functional Keywords: ketosynthase domain, cyclization, tetramic acid ring formation, nrps-pks hybrid enzyme, toxin, biosynthetic protein
• Biological source: Pyricularia oryzae 70-15 (Rice blast fungus)
• Total number of polymer chains: 2
• Total formula weight: 96223.37

Authors

Yun, C.S.,Nishimoto, K.,Motoyama, T.,Hino, T.,Nagano, S.,Osada, H. (deposition date: 2019-08-10, release date: 2020-07-01, Last modification date: 2023-11-22)

• Primary citation: Yun, C.S.,Nishimoto, K.,Motoyama, T.,Shimizu, T.,Hino, T.,Dohmae, N.,Nagano, S.,Osada, H.; Unique features of the ketosynthase domain in a nonribosomal peptide synthetase-polyketide synthase hybrid enzyme, tenuazonic acid synthetase 1.; J.Biol.Chem., 295:11602-11612, 2020; PubMed: 32565425; DOI: 10.1074/jbc.RA120.013105

Experimental method

X-RAY DIFFRACTION (1.68 Å)