6KN9
Crystal structure of human interleukin 18 receptor beta extracellular domain in complex with an antagonistic scFv
Summary for 6KN9
Entry DOI | 10.2210/pdb6kn9/pdb |
Descriptor | Interleukin-18 receptor accessory protein, scFv, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | interleukin receptor, antibody, complex, antagonist, cytokine |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 198098.10 |
Authors | |
Primary citation | Liu, S.,Miersch, S.,Li, P.,Bai, B.X,,Liu, C.C.,Qin, W.M.,Su, J.,Huang, H.M.,Pan, J.,Sidhu, S.S.,Wu, D.H. A Synthetic Human Antibody Antagonizes IL-18R beta Signaling Through an Allosteric Mechanism. J.Mol.Biol., 432:1169-1182, 2020 Cited by PubMed: 31954129DOI: 10.1016/j.jmb.2020.01.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.302 Å) |
Structure validation
Download full validation report