6KLA

Crystal structure of human c-KIT kinase domain in complex with compound 15a

Summary for 6KLA

• Entry DOI: 10.2210/pdb6kla/pdb
• Descriptor: Mast/stem cell growth factor receptor Kit, N-[6-(4-ethylpiperazin-1-yl)-2-methyl-pyrimidin-4-yl]-5-pyridin-4-yl-1,3-thiazol-2-amine (3 entities in total)
• Functional Keywords: tyrosine kinase inhibitor, kinase phosphorylation, atp competitor, transmembrane receptor protein, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 38051.06

Authors

Wu, T.S.,Peng, Y.H.,Hsueh, C.C.,Wu, S.Y. (deposition date: 2019-07-30, release date: 2019-11-27, Last modification date: 2023-11-22)

• Primary citation: Lin, W.H.,Wu, S.Y.,Yeh, T.K.,Chen, C.T.,Song, J.S.,Shiao, H.Y.,Kuo, C.C.,Hsu, T.,Lu, C.T.,Wang, P.C.,Wu, T.S.,Peng, Y.H.,Lin, H.Y.,Chen, C.P.,Weng, Y.L.,Kung, F.C.,Wu, M.H.,Su, Y.C.,Huang, K.W.,Chou, L.H.,Hsueh, C.C.,Yen, K.J.,Kuo, P.C.,Huang, C.L.,Chen, L.T.,Shih, C.,Tsai, H.J.,Jiaang, W.T.; Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia.; J.Med.Chem., 62:11135-11150, 2019; PubMed: 31721578; DOI: 10.1021/acs.jmedchem.9b01229

Experimental method

X-RAY DIFFRACTION (2.109 Å)