6KLA

Crystal structure of human c-KIT kinase domain in complex with compound 15a

6KLA の概要

• エントリーDOI: 10.2210/pdb6kla/pdb
• 分子名称: Mast/stem cell growth factor receptor Kit, N-[6-(4-ethylpiperazin-1-yl)-2-methyl-pyrimidin-4-yl]-5-pyridin-4-yl-1,3-thiazol-2-amine (3 entities in total)
• 機能のキーワード: tyrosine kinase inhibitor, kinase phosphorylation, atp competitor, transmembrane receptor protein, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38051.06

構造登録者

Wu, T.S.,Peng, Y.H.,Hsueh, C.C.,Wu, S.Y. (登録日: 2019-07-30, 公開日: 2019-11-27, 最終更新日: 2023-11-22)

• 主引用文献: Lin, W.H.,Wu, S.Y.,Yeh, T.K.,Chen, C.T.,Song, J.S.,Shiao, H.Y.,Kuo, C.C.,Hsu, T.,Lu, C.T.,Wang, P.C.,Wu, T.S.,Peng, Y.H.,Lin, H.Y.,Chen, C.P.,Weng, Y.L.,Kung, F.C.,Wu, M.H.,Su, Y.C.,Huang, K.W.,Chou, L.H.,Hsueh, C.C.,Yen, K.J.,Kuo, P.C.,Huang, C.L.,Chen, L.T.,Shih, C.,Tsai, H.J.,Jiaang, W.T.; Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia.; J.Med.Chem., 62:11135-11150, 2019; PubMed: 31721578; DOI: 10.1021/acs.jmedchem.9b01229

実験手法

X-RAY DIFFRACTION (2.109 Å)