6KJD

lovastatin esterase PcEST inactive mutant S57A in complex with lovastatin

Summary for 6KJD

• Entry DOI: 10.2210/pdb6kjd/pdb
• Descriptor: Pc15g00720 protein, (3R,5R)-7-((1R,2R,6S,8R,8AS)-2,6-DIMETHYL-8-{[(2R)-2-METHYLBUTANOYL]OXY}-1,2,6,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL)-3,5-DIHYDROXYHEPTANOIC ACID, TRIS-HYDROXYMETHYL-METHYL-AMMONIUM, ... (4 entities in total)
• Functional Keywords: family viii esterase, lovastatin hydrolysis, monacolin j, simvastatin, hydrolase
• Biological source: Penicillium rubens Wisconsin 54-1255
• Total number of polymer chains: 2
• Total formula weight: 88368.10

Authors

Liang, Y.J.,Lu, X.F. (deposition date: 2019-07-22, release date: 2019-12-25, Last modification date: 2023-11-22)

• Primary citation: Liang, Y.J.,Lu, X.F.; Structural insights into the catalytic mechanism of lovastatin hydrolase; J.Biol.Chem., 2019; DOI: 10.1074/jbc.RA119.011936

Experimental method

X-RAY DIFFRACTION (2.299 Å)