6KIK

Crystal structure of a thermostable aldo-keto reductase Tm1743 in complex with inhibitor tolrestat

Summary for 6KIK

Entry DOI	10.2210/pdb6kik/pdb
Descriptor	Oxidoreductase, aldo/keto reductase family, TOLRESTAT (3 entities in total)
Functional Keywords	aldo-ketone reductase, tolrestat, competitive inhibitor, oxidoreductase
Biological source	Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Total number of polymer chains	1
Total formula weight	31847.37
Authors	Zhang, C.Y.,Liu, X.M.,Wang, C.,Tang, W.R. (deposition date: 2019-07-18, release date: 2019-09-25, Last modification date: 2023-11-22)
Primary citation	Zhang, C.,Min, Z.,Liu, X.,Wang, C.,Wang, Z.,Shen, J.,Tang, W.,Zhang, X.,Liu, D.,Xu, X. Tolrestat acts atypically as a competitive inhibitor of the thermostable aldo-keto reductase Tm1743 from Thermotoga maritima. Febs Lett., 594:564-580, 2020 Cited by PubMed: 31573681 DOI: 10.1002/1873-3468.13630 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.601 Å)

Structure validation