6KGT
Crystal structure of Penicillin binding protein 3 (PBP3) from Mycobacterium tuerculosis, complexed with faropenem
Summary for 6KGT
Entry DOI | 10.2210/pdb6kgt/pdb |
Descriptor | Penicillin-binding protein PbpB, (2R)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-5-[(2R)-oxolan-2-yl]-2,3-dihydro-1,3-thiazole-4-carboxylic acid, COBALT (II) ION, ... (4 entities in total) |
Functional Keywords | penicillin-binding protein, native form, mycobacterium tuberculosis, faropenem, transferase |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 1 |
Total formula weight | 60281.14 |
Authors | Lu, Z.K.,Zhang, A.L.,Liu, X.,Guddat, L.,Yang, H.T.,Rao, Z.H. (deposition date: 2019-07-12, release date: 2020-03-11) |
Primary citation | Lu, Z.,Wang, H.,Zhang, A.,Liu, X.,Zhou, W.,Yang, C.,Guddat, L.,Yang, H.,Schofield, C.J.,Rao, Z. Structures ofMycobacterium tuberculosisPenicillin-Binding Protein 3 in Complex with Fivebeta-Lactam Antibiotics Reveal Mechanism of Inactivation. Mol.Pharmacol., 97:287-294, 2020 Cited by PubMed: 32086254DOI: 10.1124/mol.119.118042 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.308 Å) |
Structure validation
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