6KE4
ABloop reengineered Ferritin Nanocage
Summary for 6KE4
| Entry DOI | 10.2210/pdb6ke4/pdb |
| Descriptor | Ferritin heavy chain, FE (III) ION, MAGNESIUM ION, ... (6 entities in total) |
| Functional Keywords | rhuhf, abloop reengineered, metal binding protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 21162.82 |
| Authors | Wang, W.M.,Wang, H.F. (deposition date: 2019-07-03, release date: 2019-10-23, Last modification date: 2023-11-22) |
| Primary citation | Wang, W.,Wang, L.,Li, G.,Zhao, G.,Zhao, X.,Wang, H. AB loop engineered ferritin nanocages for drug loading under benign experimental conditions. Chem.Commun.(Camb.), 55:12344-12347, 2019 Cited by PubMed Abstract: Human ferritin has been explored as a potential drug nanocarrier, but extreme conditions (pH ≤ 2.0) are required for the encapsulation of drugs. Here, by engineering the AB loop of ferritin, we obtained a new ferritin variant with no new pores, which can disassemble at pH 3.0 or 4.0 and reassemble at pH 7.0. Consequently, under mild conditions, drugs can be encapsulated within this new ferritin nanocage. PubMed: 31556881DOI: 10.1039/c9cc05247j PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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