6KCM

Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613S with pterin and p-hydrobenzoate

Summary for 6KCM

Entry DOI	10.2210/pdb6kcm/pdb
Descriptor	7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, PTERINE, P-HYDROXYBENZOIC ACID, ... (9 entities in total)
Functional Keywords	tim barrel, kinase, transferase
Biological source	Plasmodium falciparum
Total number of polymer chains	2
Total formula weight	174087.03
Authors	Chitnumsub, P.,Jaruwat, A.,Yuthavong, Y. (deposition date: 2019-06-28, release date: 2020-02-12, Last modification date: 2023-11-22)
Primary citation	Chitnumsub, P.,Jaruwat, A.,Talawanich, Y.,Noytanom, K.,Liwnaree, B.,Poen, S.,Yuthavong, Y. The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287:3273-3297, 2020 Cited by PubMed: 31883412 DOI: 10.1111/febs.15196 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation