6KBR

Crystal structure of Human KLK4 and SPINK2 derived KLK4 inhibitor complex

Summary for 6KBR

Entry DOI	10.2210/pdb6kbr/pdb
Descriptor	Kallikrein-4, K41043, GLYCEROL, ... (4 entities in total)
Functional Keywords	protein engineering, cystine knot protein, protease inhibitor, structural analysis, protein binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	34400.10
Authors	Kawaguchi, Y.,Nishimiya, D. (deposition date: 2019-06-26, release date: 2019-07-17, Last modification date: 2023-11-22)
Primary citation	Nishimiya, D.,Kawaguchi, Y.,Kodama, S.,Nasu, H.,Yano, H.,Yamaguchi, A.,Tamura, M.,Hashimoto, R. A protein scaffold, engineered SPINK2, for generation of inhibitors with high affinity and specificity against target proteases. Sci Rep, 9:11436-11436, 2019 Cited by PubMed: 31391482 DOI: 10.1038/s41598-019-47615-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation