6KBR
Crystal structure of Human KLK4 and SPINK2 derived KLK4 inhibitor complex
Summary for 6KBR
Entry DOI | 10.2210/pdb6kbr/pdb |
Descriptor | Kallikrein-4, K41043, GLYCEROL, ... (4 entities in total) |
Functional Keywords | protein engineering, cystine knot protein, protease inhibitor, structural analysis, protein binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 34400.10 |
Authors | Kawaguchi, Y.,Nishimiya, D. (deposition date: 2019-06-26, release date: 2019-07-17, Last modification date: 2023-11-22) |
Primary citation | Nishimiya, D.,Kawaguchi, Y.,Kodama, S.,Nasu, H.,Yano, H.,Yamaguchi, A.,Tamura, M.,Hashimoto, R. A protein scaffold, engineered SPINK2, for generation of inhibitors with high affinity and specificity against target proteases. Sci Rep, 9:11436-11436, 2019 Cited by PubMed: 31391482DOI: 10.1038/s41598-019-47615-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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