6KBR

Crystal structure of Human KLK4 and SPINK2 derived KLK4 inhibitor complex

6KBR の概要

• エントリーDOI: 10.2210/pdb6kbr/pdb
• 分子名称: Kallikrein-4, K41043, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: protein engineering, cystine knot protein, protease inhibitor, structural analysis, protein binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34400.10

構造登録者

Kawaguchi, Y.,Nishimiya, D. (登録日: 2019-06-26, 公開日: 2019-07-17, 最終更新日: 2023-11-22)

• 主引用文献: Nishimiya, D.,Kawaguchi, Y.,Kodama, S.,Nasu, H.,Yano, H.,Yamaguchi, A.,Tamura, M.,Hashimoto, R.; A protein scaffold, engineered SPINK2, for generation of inhibitors with high affinity and specificity against target proteases.; Sci Rep, 9:11436-11436, 2019; PubMed: 31391482; DOI: 10.1038/s41598-019-47615-5

実験手法

X-RAY DIFFRACTION (2 Å)