6K7W

Solution Structure of the CS1 Domain of USP19

Summary for 6K7W

• Entry DOI: 10.2210/pdb6k7w/pdb
• Descriptor: Ubiquitin carboxyl-terminal hydrolase 19 (1 entity in total)
• Functional Keywords: cs domain, autoinhibitory regulation, hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 10150.73

Authors

Xue, W.,Hu, H.Y. (deposition date: 2019-06-10, release date: 2020-06-10, Last modification date: 2024-05-15)

• Primary citation: Xue, W.,Zhang, S.X.,He, W.T.,Hong, J.Y.,Jiang, L.L.,Hu, H.Y.; Domain interactions reveal auto-inhibition of the deubiquitinating enzyme USP19 and its activation by HSP90 in the modulation of huntingtin aggregation.; Biochem.J., 477:4295-4312, 2020; PubMed: 33094816; DOI: 10.1042/BCJ20200536

Experimental method

SOLUTION NMR