6K5V
Structure of CSY4 Apo-form
Summary for 6K5V
| Entry DOI | 10.2210/pdb6k5v/pdb |
| Descriptor | Citrate synthase 4, mitochondrial, CHLORIDE ION (3 entities in total) |
| Functional Keywords | citrate synthase, mitochondrial, plant, csy4, transferase |
| Biological source | Arabidopsis thaliana (Mouse-ear cress) |
| Total number of polymer chains | 6 |
| Total formula weight | 305606.51 |
| Authors | Nishio, K.,Mizushima, T. (deposition date: 2019-05-31, release date: 2020-03-18, Last modification date: 2023-11-22) |
| Primary citation | Nishio, K.,Mizushima, T. Structural and biochemical characterization of mitochondrial citrate synthase 4 from Arabidopsis thaliana. Acta Crystallogr.,Sect.F, 76:109-115, 2020 Cited by PubMed Abstract: Citrate synthase (CS) catalyzes the conversion of oxaloacetate and acetyl coenzyme A into citrate and coenzyme A in the mitochondrial tricarboxylic acid (TCA) cycle. In plants, mitochondrial metabolism, including the TCA cycle, occurs in interaction with photosynthetic metabolism. The controlled regulation of several enzymes in the TCA cycle, such as CS, is important in plants. Here, the first crystal structure of a plant mitochondrial CS, CSY4 from Arabidopsis thaliana (AtCSY4), has been determined. Structural comparison of AtCSY4 with mitochondrial CSs revealed a high level of similarity. Inhibition analysis showed a similar manner of inhibition as in mitochondrial CSs. The effect of oxidation on one of a pair of cysteine residues in AtCSY4 was speculated upon based on the folded structure. PubMed: 32133996DOI: 10.1107/S2053230X20001521 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.69 Å) |
Structure validation
Download full validation report
