6K1S
Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase (PRMT5) Inhibitors
Summary for 6K1S
Entry DOI | 10.2210/pdb6k1s/pdb |
Descriptor | Protein arginine N-methyltransferase 5, Methylosome protein 50, 2-[[7-[(2~{R},3~{R},4~{S},5~{R})-5-[(~{R})-(4-chlorophenyl)-oxidanyl-methyl]-3,4-bis(oxidanyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidin-4-yl]amino]ethanal, ... (6 entities in total) |
Functional Keywords | prmt5, complex, covalent, inhibitor, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 112557.47 |
Authors | |
Primary citation | Lin, H.,Wang, M.,Zhang, Y.W.,Tong, S.,Leal, R.A.,Shetty, R.,Vaddi, K.,Luengo, J.I. Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors. Acs Med.Chem.Lett., 10:1033-1038, 2019 Cited by PubMed: 31312404DOI: 10.1021/acsmedchemlett.9b00074 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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