6K1S

Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase (PRMT5) Inhibitors

6K1S の概要

• エントリーDOI: 10.2210/pdb6k1s/pdb
• 分子名称: Protein arginine N-methyltransferase 5, Methylosome protein 50, 2-[[7-[(2~{R},3~{R},4~{S},5~{R})-5-[(~{R})-(4-chlorophenyl)-oxidanyl-methyl]-3,4-bis(oxidanyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidin-4-yl]amino]ethanal, ... (6 entities in total)
• 機能のキーワード: prmt5, complex, covalent, inhibitor, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 112557.47

構造登録者

Tong, S.,Lin, H. (登録日: 2019-05-12, 公開日: 2019-06-19, 最終更新日: 2023-11-22)

• 主引用文献: Lin, H.,Wang, M.,Zhang, Y.W.,Tong, S.,Leal, R.A.,Shetty, R.,Vaddi, K.,Luengo, J.I.; Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors.; Acs Med.Chem.Lett., 10:1033-1038, 2019; PubMed: 31312404; DOI: 10.1021/acsmedchemlett.9b00074

実験手法

X-RAY DIFFRACTION (2.6 Å)