6K18

Crystal structure of EXD2 exonuclease domain soaked in Mn

Summary for 6K18

DescriptorExonuclease 3'-5' domain-containing protein 2, MANGANESE (II) ION (3 entities in total)
Functional Keywords3'-5' exonuclease, dnaq family, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight48902.37
Authors
Park, J.,Lee, C. (deposition date: 2019-05-10, release date: 2019-05-22, Last modification date: 2019-12-04)
Primary citation
Park, J.,Lee, S.Y.,Jeong, H.,Kang, M.G.,Van Haute, L.,Minczuk, M.,Seo, J.K.,Jun, Y.,Myung, K.,Rhee, H.W.,Lee, C.
The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.
Nucleic Acids Res., 47:7078-7093, 2019
PubMed: 31127291 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gkz454
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.303 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.29040 0.3% 8.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload