6JWW

Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613T triple mutant with STZ-DHP

Summary for 6JWW

• Entry DOI: 10.2210/pdb6jww/pdb
• Descriptor: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, 4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}-N-(1,3-thiazol-2-yl)benzenesulfonamide, 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, ... (9 entities in total)
• Functional Keywords: tim barrel, kinase, transferase
• Biological source: Plasmodium falciparum (malaria parasite P. falciparum)
• Total number of polymer chains: 2
• Total formula weight: 174346.64

Authors

Chitnumsub, P.,Jaruwat, A.,Yuthavong, Y. (deposition date: 2019-04-21, release date: 2020-02-12, Last modification date: 2023-11-22)

• Primary citation: Chitnumsub, P.,Jaruwat, A.,Talawanich, Y.,Noytanom, K.,Liwnaree, B.,Poen, S.,Yuthavong, Y.; The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.; Febs J., 287:3273-3297, 2020; PubMed: 31883412; DOI: 10.1111/febs.15196

Experimental method

X-RAY DIFFRACTION (2.75 Å)