6JWW
Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613T triple mutant with STZ-DHP
Summary for 6JWW
Entry DOI | 10.2210/pdb6jww/pdb |
Descriptor | 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, 4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}-N-(1,3-thiazol-2-yl)benzenesulfonamide, 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, ... (9 entities in total) |
Functional Keywords | tim barrel, kinase, transferase |
Biological source | Plasmodium falciparum (malaria parasite P. falciparum) |
Total number of polymer chains | 2 |
Total formula weight | 174346.64 |
Authors | Chitnumsub, P.,Jaruwat, A.,Yuthavong, Y. (deposition date: 2019-04-21, release date: 2020-02-12, Last modification date: 2023-11-22) |
Primary citation | Chitnumsub, P.,Jaruwat, A.,Talawanich, Y.,Noytanom, K.,Liwnaree, B.,Poen, S.,Yuthavong, Y. The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287:3273-3297, 2020 Cited by PubMed: 31883412DOI: 10.1111/febs.15196 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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