6JWQ

Crystal structure of Plasmodium falciparum HPPK-DHPS wild type

Summary for 6JWQ

• Entry DOI: 10.2210/pdb6jwq/pdb
• Descriptor: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ... (7 entities in total)
• Functional Keywords: tim barrel, kinase, transferase
• Biological source: Plasmodium falciparum (malaria parasite P. falciparum)
• Total number of polymer chains: 2
• Total formula weight: 172976.16

Authors

Chitnumsub, P.,Jaruwat, A.,Yuthavong, Y. (deposition date: 2019-04-21, release date: 2020-02-12, Last modification date: 2024-03-27)

• Primary citation: Chitnumsub, P.,Jaruwat, A.,Talawanich, Y.,Noytanom, K.,Liwnaree, B.,Poen, S.,Yuthavong, Y.; The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.; Febs J., 287:3273-3297, 2020; PubMed: 31883412; DOI: 10.1111/febs.15196

Experimental method

X-RAY DIFFRACTION (2.5 Å)