6JR4

Crystal structure of a NIR-emitting DNA-stabilized Ag16 nanocluster

6JR4 の概要

• エントリーDOI: 10.2210/pdb6jr4/pdb
• 分子名称: DNA (5'-D(*CP*AP*CP*CP*TP*AP*GP*CP*GP*A)-3'), SILVER ION, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: nanocluster, silver, dna
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 16235.12

構造登録者

Kondo, J.,Cerretani, C.,Kanazawa, H.,Vosch, T. (登録日: 2019-04-02, 公開日: 2019-08-28, 最終更新日: 2024-03-27)

主引用文献

Cerretani, C.,Kanazawa, H.,Vosch, T.,Kondo, J.
Crystal structure of a NIR-Emitting DNA-Stabilized Ag16Nanocluster.
Angew.Chem.Int.Ed.Engl., 58:17153-17157, 2019

PubMed Abstract: DNA has been used as a scaffold to stabilize small, atomically monodisperse silver nanoclusters, which have attracted attention due to their intriguing photophysical properties. Herein, we describe the X-ray crystal structure of a DNA-encapsulated, near-infrared emitting Ag nanocluster (DNA-Ag NC). The asymmetric unit of the crystal contains two DNA-Ag NCs and the crystal packing between the DNA-Ag NCs is promoted by several interactions, such as two silver-mediated base pairs between 3'-terminal adenines, two phosphate-Ca -phosphate interactions, and π-stacking between two neighboring thymines. Each Ag NC is confined by two DNA decamers that take on a horse-shoe-like conformation and is almost fully shielded from the solvent environment. This structural insight will aid in the determination of the structure/photophysical property relationship for this class of emitters and opens up new research opportunities in fluorescence imaging and sensing using noble-metal clusters.

PubMed: 31411360
DOI: 10.1002/anie.201906766

実験手法

X-RAY DIFFRACTION (1.798 Å)