6JLR

Crystal structure of wild type MNK2 in complex with inhibitor

Summary for 6JLR

Entry DOI	10.2210/pdb6jlr/pdb
Descriptor	MAP kinase-interacting serine/threonine-protein kinase 2, 4-[5-(1-methylpyrazol-4-yl)pyridin-3-yl]benzamide (2 entities in total)
Functional Keywords	kinase, phosphorylation, inhibitor, mnk, kinase domain, transferase, cancer, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	35940.81
Authors	Baburajendran, N.,Hill, J. (deposition date: 2019-03-06, release date: 2020-02-12, Last modification date: 2023-11-22)
Primary citation	Kwiatkowski, J.,Liu, B.,Pang, S.,Ahmad, N.H.B.,Wang, G.,Poulsen, A.,Yang, H.,Poh, Y.R.,Tee, D.H.Y.,Ong, E.,Retna, P.,Dinie, N.,Kwek, P.,Wee, J.L.K.,Manoharan, V.,Low, C.B.,Seah, P.G.,Pendharkar, V.,Sangthongpitag, K.,Joy, J.,Baburajendran, N.,Jansson, A.E.,Nacro, K.,Hill, J.,Keller, T.H.,Hung, A.W. Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2. J.Med.Chem., 63:621-637, 2020 Cited by PubMed: 31910010 DOI: 10.1021/acs.jmedchem.9b01582 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.901 Å)

Structure validation