6JLR

Crystal structure of wild type MNK2 in complex with inhibitor

6JLR の概要

• エントリーDOI: 10.2210/pdb6jlr/pdb
• 分子名称: MAP kinase-interacting serine/threonine-protein kinase 2, 4-[5-(1-methylpyrazol-4-yl)pyridin-3-yl]benzamide (2 entities in total)
• 機能のキーワード: kinase, phosphorylation, inhibitor, mnk, kinase domain, transferase, cancer, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35940.81

構造登録者

Baburajendran, N.,Hill, J. (登録日: 2019-03-06, 公開日: 2020-02-12, 最終更新日: 2023-11-22)

• 主引用文献: Kwiatkowski, J.,Liu, B.,Pang, S.,Ahmad, N.H.B.,Wang, G.,Poulsen, A.,Yang, H.,Poh, Y.R.,Tee, D.H.Y.,Ong, E.,Retna, P.,Dinie, N.,Kwek, P.,Wee, J.L.K.,Manoharan, V.,Low, C.B.,Seah, P.G.,Pendharkar, V.,Sangthongpitag, K.,Joy, J.,Baburajendran, N.,Jansson, A.E.,Nacro, K.,Hill, J.,Keller, T.H.,Hung, A.W.; Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2.; J.Med.Chem., 63:621-637, 2020; PubMed: 31910010; DOI: 10.1021/acs.jmedchem.9b01582

実験手法

X-RAY DIFFRACTION (2.901 Å)