6JF0

Covalent labeling of hPPARg-LBD by turn-on fluorescent probe mediated by conjugate addition and cyclization

6JF0 の概要

• エントリーDOI: 10.2210/pdb6jf0/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, methyl (2~{S})-3-[4-[3-(4-methoxy-2-oxidanyl-phenyl)prop-2-ynoyloxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoate, 7-methoxychromen-2-one, ... (4 entities in total)
• 機能のキーワード: receptor, covalent labeling, cysteine, turn-on fluorescent probe, tcc probe, nuclear protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63624.78

構造登録者

Kojima, H.,Yamamoto, K.,Itoh, T. (登録日: 2019-02-07, 公開日: 2020-02-12, 最終更新日: 2023-11-22)

• 主引用文献: Kojima, H.,Fujita, Y.,Takeuchi, R.,Ikebe, Y.,Ohashi, N.,Yamamoto, K.,Itoh, T.; Cyclization Reaction-Based Turn-on Probe for Covalent Labeling of Target Proteins.; Cell Chem Biol, 27:334-, 2020; PubMed: 31991094; DOI: 10.1016/j.chembiol.2020.01.006

実験手法

X-RAY DIFFRACTION (3.4 Å)