6JAY

Crystal structure of Ostrinia furnacalis Group II chitinase catalytic domain 1 in complex with a dipyrido-pyrimidine derivative

Summary for 6JAY

• Entry DOI: 10.2210/pdb6jay/pdb
• Related: 5Y29
• Descriptor: Group II chitinase, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-1-[(furan-2-yl)methyl]-5-oxo-3-({[(2S)-oxolan-2-yl]methyl}carbamoyl)-5H-dipyrido[1,2-a:2',3'-d]pyrimidin-1-ium, ... (4 entities in total)
• Functional Keywords: inhibitor complex, chitinase, hydrolase
• Biological source: Ostrinia furnacalis (Asian corn borer)
• Total number of polymer chains: 1
• Total formula weight: 45110.04

Authors

Chen, W.,Zhou, Y.,Yang, Q. (deposition date: 2019-01-25, release date: 2019-05-15, Last modification date: 2023-11-22)

• Primary citation: Chen, W.,Zhou, Y.,Yang, Q.; Structural dissection reveals a general mechanistic principle for group II chitinase (ChtII) inhibition.; J.Biol.Chem., 294:9358-9364, 2019; PubMed: 31053640; DOI: 10.1074/jbc.RA119.007812

Experimental method

X-RAY DIFFRACTION (1.498 Å)