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6J8R

Metallo-Beta-Lactamase VIM-2 in complex with Dual MBL/SBL Inhibitor MS01

Summary for 6J8R
Entry DOI10.2210/pdb6j8r/pdb
DescriptorBeta-lactamase class B VIM-2, ZINC ION, [[(2S)-2-methyl-3-sulfanyl-propanoyl]amino]methylboronic acid, ... (6 entities in total)
Functional Keywordsmetallo-beta-lactamase vim-2, vim-2, hydrolase
Biological sourcePseudomonas aeruginosa
Total number of polymer chains1
Total formula weight25585.74
Authors
Li, G.-B.,Liu, S. (deposition date: 2019-01-21, release date: 2019-07-17, Last modification date: 2023-11-22)
Primary citationWang, Y.L.,Liu, S.,Yu, Z.J.,Lei, Y.,Huang, M.Y.,Yan, Y.H.,Ma, Q.,Zheng, Y.,Deng, H.,Sun, Y.,Wu, C.,Yu, Y.,Chen, Q.,Wang, Z.,Wu, Y.,Li, G.B.
Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-beta-lactamases.
J.Med.Chem., 62:7160-7184, 2019
Cited by
PubMed: 31269398
DOI: 10.1021/acs.jmedchem.9b00735
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.575 Å)
Structure validation

217705

数据于2024-03-27公开中

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