6IUO

Crystal structure of FGFR4 kinase domain in complex with a covalent inhibitor

Summary for 6IUO

• Entry DOI: 10.2210/pdb6iuo/pdb
• Descriptor: Fibroblast growth factor receptor 4, N-({4-[4-amino-3-(3,5-dimethyl-1-benzofuran-2-yl)-7-oxo-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-2-yl]phenyl}methyl)prop-2-enamide (3 entities in total)
• Functional Keywords: protein kinase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 36417.86

Authors

Xu, Y.,Liu, Q. (deposition date: 2018-11-29, release date: 2019-10-23, Last modification date: 2023-11-22)

• Primary citation: Wang, Y.,Dai, Y.,Wu, X.,Li, F.,Liu, B.,Li, C.,Liu, Q.,Zhou, Y.,Wang, B.,Zhu, M.,Cui, R.,Tan, X.,Xiong, Z.,Liu, J.,Tan, M.,Xu, Y.,Geng, M.,Jiang, H.,Liu, H.,Ai, J.,Zheng, M.; Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design.; J.Med.Chem., 62:7473-7488, 2019; PubMed: 31335138; DOI: 10.1021/acs.jmedchem.9b00510

Experimental method

X-RAY DIFFRACTION (2.3 Å)