6IUO

Crystal structure of FGFR4 kinase domain in complex with a covalent inhibitor

6IUO の概要

• エントリーDOI: 10.2210/pdb6iuo/pdb
• 分子名称: Fibroblast growth factor receptor 4, N-({4-[4-amino-3-(3,5-dimethyl-1-benzofuran-2-yl)-7-oxo-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-2-yl]phenyl}methyl)prop-2-enamide (3 entities in total)
• 機能のキーワード: protein kinase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36417.86

構造登録者

Xu, Y.,Liu, Q. (登録日: 2018-11-29, 公開日: 2019-10-23, 最終更新日: 2023-11-22)

• 主引用文献: Wang, Y.,Dai, Y.,Wu, X.,Li, F.,Liu, B.,Li, C.,Liu, Q.,Zhou, Y.,Wang, B.,Zhu, M.,Cui, R.,Tan, X.,Xiong, Z.,Liu, J.,Tan, M.,Xu, Y.,Geng, M.,Jiang, H.,Liu, H.,Ai, J.,Zheng, M.; Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design.; J.Med.Chem., 62:7473-7488, 2019; PubMed: 31335138; DOI: 10.1021/acs.jmedchem.9b00510

実験手法

X-RAY DIFFRACTION (2.3 Å)