6IUE

DNA helical wire containing Hg(II)

Summary for 6IUE

• Entry DOI: 10.2210/pdb6iue/pdb
• Descriptor: DNA (5'-D(*TP*TP*TP*GP*C)-3'), MERCURY (II) ION (3 entities in total)
• Functional Keywords: nanowire, mercury, metallo-base pair, dna
• Biological source: synthetic construct
• Total number of polymer chains: 24
• Total formula weight: 45292.54

Authors

Ono, A.,Kanazawa, H.,Ito, H.,Goto, M.,Nakamura, K.,Saneyoshi, H.,Kondo, J. (deposition date: 2018-11-28, release date: 2019-10-16, Last modification date: 2024-03-27)

Primary citation

Ono, A.,Kanazawa, H.,Ito, H.,Goto, M.,Nakamura, K.,Saneyoshi, H.,Kondo, J.
A Novel DNA Helical Wire Containing HgII-Mediated T:T and T:G Pairs.
Angew.Chem.Int.Ed.Engl., 58:16835-16838, 2019

PubMed Abstract: Numerous applications of metal-mediated base pairs (metallo-base-pairs) to nucleic acid based nanodevices and genetic code expansion have been extensively studied. Many of these metallo-base-pairs are formed in DNA and RNA duplexes containing Watson-Crick base pairs. Recently, a crystal structure of a metal-DNA nanowire with an uninterrupted one-dimensional silver array was reported. We now report the crystal structure of a novel DNA helical wire containing Hg -mediated T:T and T:G base pairs and water-mediated C:C base pairs. The Hg-DNA wire does not contain any Watson-Crick base pairs. Crystals of the Hg-DNA wire, which is the first DNA wire structure driven by Hg ions, were obtained by mixing the short oligonucleotide d(TTTGC) and Hg ions. This study demonstrates the potential of metallo-DNA to form various structural components that can be used for functional nanodevices.

PubMed: 31507027
DOI: 10.1002/anie.201910029

Experimental method

X-RAY DIFFRACTION (1.901 Å)