6ITJ

Crystal structure of FGFR1 kinase domain in complex with compound 3

Summary for 6ITJ

Entry DOI	10.2210/pdb6itj/pdb
Descriptor	Fibroblast growth factor receptor 1, 4-azanyl-3-(3,5-dimethyl-1-benzofuran-2-yl)-2-phenyl-6~{H}-pyrazolo[3,4-d]pyridazin-7-one (3 entities in total)
Functional Keywords	protein kinase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	70899.35
Authors	Xu, Y.,Liu, Q. (deposition date: 2018-11-23, release date: 2019-10-23, Last modification date: 2023-11-22)
Primary citation	Wang, Y.,Dai, Y.,Wu, X.,Li, F.,Liu, B.,Li, C.,Liu, Q.,Zhou, Y.,Wang, B.,Zhu, M.,Cui, R.,Tan, X.,Xiong, Z.,Liu, J.,Tan, M.,Xu, Y.,Geng, M.,Jiang, H.,Liu, H.,Ai, J.,Zheng, M. Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design. J.Med.Chem., 62:7473-7488, 2019 Cited by PubMed: 31335138 DOI: 10.1021/acs.jmedchem.9b00510 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.994 Å)

Structure validation